Course Number: KIN 446
Course Title: Neurobiology of Disease
Credit Hours: 3 Vector: 3-0-0
Course Description
Examines neural and neuromuscular diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, stroke, and myasthenia gravis. Emphasizes currently favoured hypotheses, underlying evidence and pathogenic mechanisms.
Prerequisite: KIN 306.
Recommended: KIN 336 and/or KIN 415.
Corequisite: None.
Special Instructions: None.
Course(s) to be dropped if this course is approved: None.
This course is an elective course in the curriculum, with a probable enrolment of 30 students. It has been previously run as KIN 421 with 30 students. As indicated in the course outline, the purpose of the course is to examine the mechanism by which abnormalities occur in nervous system disease with special emphasis on those diseases which are relevant for Kinesiology. The abnormal mechanisms of the diseases will be evaluated at cellular and systems levels and the course will be directed to the understanding of specific diseases. Diseases are chosen for study as a paradigm for a given mechanism by which disorder is believed to occur. Specific diseases to be considered include Alzheimer’s disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Myasthenia Gravis and others.
The aim of this course is to provide final year Kinesiology students with further training in physiology and applied physiology so as to be able to better understand diseases affecting patients with neurological problems. This will be of particular interest to students who are interested in dealing with patients with neurologic disease or who are intending to do further studies in nervous system function and dysfunction.
Indicate Semester and Year this course would be first offered and planned frequency of offering thereafter.
This course would be offered in the Fall term and would be offered once a year. It will be offered as a KIN 421 in the next Fall term.
Which of your present CFL faculty have the expertise to offer this course? Will the course be taught by sessional or limited term faculty?
The course will be taught by Dr. Charles Krieger who has expertise to offer this course.
Are there any proposed student fees associated with this course other than tuition fees?
Is this course considered a `duplicate' of any current or prior course under the University's duplicate course policy? Specify, as appropriate.
No, there is no overlap between this course and any other in the Calendar. This course may compliment courses stressing the physiology of the normal nervous system (eg. KIN 306, KIN 415) as well as courses dealing with musculoskeletal disorders (KIN 481).
Note: Senate has approved (S.93-11) that no new course should be approved by Senate until funding has been committed for necessary library materials. Each new course proposal must be accompanied by a library report and, if appropriate, confirmation that funding arrangements have been addressed.
Provide details on how existing instructional resources will be redistributed to accommodate this new course. For instance, will another course be eliminated or will the frequency of offering of other courses be reduced; are there changes in pedagogical style or class sizes that allow for this additional course offering.
The proposed instructor is a new faculty member and does not have other currently offered courses. There is a perceived need for a course examining the issues which will be discussed in the proposed course. Student feedback from the initial offering of this course indicated that it was valuable (3.60 score in student evaluation, n=25); and it was rated overall at 3.56 (n=25). This ranking was third in the 28 courses offered by Kinesiology, during that term.
Does the course require specialized space or equipment not readily available in the department or university, and if so, how will these resources be provided?
No, not applicable.
Does this course require computing resources (e.g. hardware, software, network wiring, use of computer laboratory space) and if so, describe how they will be provided.
Not necessary.
Kin 446
Instructor: C. Krieger
Office: K8636
Tel: 291-3753
The purpose of this course is to examine pathogenic mechanisms underlying several important neural and neuromuscular diseases. We will study a variety of important neurological diseases especially from the standpoint of how these diseases occur. The disorders which will be considered include Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis, stroke, myasthenia gravis and others. The emphasis will be on the currently favoured hypotheses for these diseases and evidence by which these diseases will develop. Although the lectures will be general, the student will be expected to have a reasonable background in the anatomy and physiology of the nervous system. Students must have completed Kin 306, (or equivalent). It is recommended that students have taken or are taking KIN 415 and/ or KIN 326 and KIN 336. The intended audience is final year kinesiology students interested in further studies exploring the pathogenesis of neuromuscular disease or students interested in dealing with patients with neurological disease.
There will be a two hour lecture and a one hour seminar per week. In the early part of this course the seminar hour will be used for questions and further discussion, but later it will be used for student presentations. Students will discuss the topic using several reference papers. The rough organization of the course is that it will comprise roughly 13 different topics run for each week.
final exam: 40%
1st midterm: 15%
2nd midterm: 25%
presentation or paper on topic of choice: 20%
No textbook is required. We will use custom courseware.
Are the current SFU library resources adequate for this course?
Will use custom courseware
What additional library resources are essential for the offering of this course?
Currently we have one copy of the recommended textbook in the SFU Library. I believe we will likely need a second copy, and these two copies should be kept on reserve during the period the course is offered. The book is entitled, Scientific American Molecular Neurology, Martin, J. B., editor. call number # RC347 S37, 1998. We will only be reviewing several of the topics in this book, thus permitting the students to copy specific chapters or chapters they find of interest.
We will also be reviewing material from a chapter from another library book entitled, Amyotrophic Lateral Sclerosis, by Eisen and Krieger. Call number # RC406 A24 E37, 1998. This book will also be put on reserve during the period of the course. It is unlikely that students would be expected to review more than 10% of this book. A new copy would be desirable but not necessary.
Other reference material or readings would be available from journals in the library, such as Nature, Science or a course syllabus on CD which I will leave in the library during the duration of the course.
What additional library resources, if any, would be desirable but not essential for the offering of this course?
None.